2-substituted ergoline urea and thio-urea derivatives having neu

Details 2-substituted ergoline urea and thio-urea derivatives having neu 2-substituted ergoline urea and thio-urea derivatives having neu

1986-10-06

1989-05-02

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 544333, 546 68, A61K 3148, C07D45712

Patent

active

048268518

ABSTRACT:
Novel 2-substituted ergolinyl urea and thioruea derivatives are disclosed, as well as their use as pharmaceuticals, specifically as neuroleptics. The compounds, which possess central dopaminergic activity, have the formula ##STR1## wherein X is an oxygen or sulfur atom,

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patent: 4382940 (1983-05-01), Bernardi et al.
patent: 4500712 (1985-02-01), Bernardi et al.
Berde et al., Ergot Alkaloids and Related Compounds, Springer-Verlag, New York (1978), pp. 74, 469-470.
Pratt et al., Organosilicon Compounds, XX, J. Org. Chem., vol. 40 (1975), pp. 1090-1093.

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