2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmac

Details 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmac 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmac

1987-02-27

1989-05-16

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514257, 514267, 544247, 544251, A61K 31505, C07D47114, C07D48704, C07D48714

Patent

active

048310131

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is optionally substituted phenyl, pyridyl, thienyl, furyl, pyrrolyl, thiazolyl, or ribofuranosyl; X is oxygen, NR, or sulfur; R is hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and ring A is (a) an optionally substituted 5-8 membered monocycloalken-1,2-diyl; (b) an optionally substituted carbobicyclic ring of the formula ##STR2## wherein n and m are each independently one or two; or (c) an optionally substituted 5-6 membered heterocycle having one or two heteroatoms, the atoms of which are selected from carbon, oxygen, nitrogen, and sulfur. Also disclosed are tautomers of the above and pharmaceutically acceptable salts; compositions thereof; and methods of using the compounds, tautomer, or salts.

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