2-Substituted benzisothiazol-3-ones

Details 2-Substituted benzisothiazol-3-ones 2-Substituted benzisothiazol-3-ones

1977-05-23

1978-08-29

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26029357, 2602948C, 424263, 424267, 544368, A61K 31495, C07D41706

Patent

active

041104498

ABSTRACT:
2-Substituted benzisothiazol-3-ones are provided having the structure ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, or nitro; R.sup.1 is hydrogen, lower alkoxy or halogen, with the proviso that R.sup.1 can be lower alkoxy or halogen only when R is lower alkoxy or halogen, respectively; X is hydrogen, halogen, lower alkyl, lower alkoxy, or trifluoromethyl; Y is C or N, where Y is C, --------represents a single or double bond, and when Y is N, --------represents a single bond, p is 0 or 2, A is an alkylene group containing 2 to 5 carbons in the normal chain; and B is a single bond or an alkylene group containing from 1 to 3 carbons in the normal chain, and physiologically acceptable acid-addition salts thereof.
These compounds have antiinflammatory activity, sedative and muscle relaxant activity. Pharmaceutical compositions containing such compounds and methods for using such compounds are also provided.

REFERENCES:
patent: 2751392 (1956-06-01), Grogan et al.
patent: 3457272 (1969-07-01), Crook et al.

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