2-substituted benzimidazole derivatives as selective melanin...

Details 2-substituted benzimidazole derivatives as selective melanin... 2-substituted benzimidazole derivatives as selective melanin...

2007-05-08

2007-05-08

Aulakh, Charanjit S. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S199000, C546S198000, C546S194000, C546S016000, C514S321000, C514S318000, C514S278000

Reexamination Certificate

active

10924070

ABSTRACT:
The present invention discloses compounds of formula Iwherein Ar, X, R1and R11are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

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International Search Report for PCT/US2004/027240 (CN06099US01) - 5 Pages.
Shamada et al., Mice lacking melanin-concentrating hormone are hypophagic and lean, Nature, vol. 396 (Dec. 17, 1998) 670-674.
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Burckhalter, J. H. et al., 2-(2-pYRIDYL)-1,2-diarylalkanols as hypocholesteremic agents, Journal of Med. Chem. American Chem. Society 10:4 (Jul. 1967) 565-575 XP002904134.
Beth Borowsky et al., Antidepressant, anxiolytic and anorectic effects. . Nature Medicine, 8:8 (Aug. 2002) 825-830.

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