2-substituted arabinopyranosyl nucleosides and nucleotides

Details 2-substituted arabinopyranosyl nucleosides and nucleotides 2-substituted arabinopyranosyl nucleosides and nucleotides

1986-10-14

1990-04-17

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 50, 536 41, 536 173, 536 181, 536 184, 536 23, 536 24, 536120, 536122, A61K 3170, C07H 1502

Patent

active

049180568

ABSTRACT:
Novel arabinopyranosyl nucleoside derivatives having the heterocyclic moiety and fluorine at the 2' position of the sugar ring (pyranose configuration), which have antitumor, antiviral and antimicrobial properties, are prepared by condensation of a pyrimidine, purine or 1,3-oxazine base with an acylated 2-deoxy-2,2-difluoro-D-arabinopyranoside and/or acylated 2-deoxy-2-bromo-2-fluoro-D-arabinopyranoside.

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Bernacki et al.; Cancer Research 45: 695, 1985.
Bergstrom et al., Synthesis of Gem-Difluoro Substituted Nucleoside Analogs, Abstract from mtg of American Chemical Society, 1985.
Grindey et al., Antitumor Activity of 2',2'-difluorodeoxycytidine, Proceedings of AACR, vol. 27, Mar. 1986.
Kroin et al., A Practical Synthesis of 2'-deoxy-2'2'-difluoro-D-Ribofuranosyl Nucleosides, Abstract from mtg of American Chemical Society, 1986.
Hertel et al., A Simple and Stereocontrolled Synthesis of 2-Deoxy-2,2-Defluoro-D-Ribose, Abstract from mtg of American Chemical Society, 1986.

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