2-Substituted arabinofuranosyl nucleosides and nucleotides

Details 2-Substituted arabinofuranosyl nucleosides and nucleotides 2-Substituted arabinofuranosyl nucleosides and nucleotides

1978-05-12

1980-10-28

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 23, 536 24, 536 27, 536 28, 536 29, A61K 3170, C07H 1700, C07H 1512, C07H 1700

Patent

active

042306981

ABSTRACT:
Novel arabinofuranosyl nucleosides and nucleotides having 2'-azido, 2'-amino, or 2'-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1,3-oxazine base with an acylated 2-azido-2-deoxyarabinofuranosyl halide, followed by deblocking and catalytic hydrogenation, where appropriate, to convert the 2'-azido group to a 2'-amino group and, if desired, alkylation or the like to convert the 2'-amino group to a 2'-hydrocarbylamino group.

REFERENCES:
patent: 3116282 (1963-12-01), Hunter
patent: 3501456 (1970-03-01), Shen et al.
patent: 3755295 (1973-08-01), Verheyden et al.
patent: 3809689 (1974-05-01), Damadaran et al.
patent: 3987030 (1976-10-01), Suzuki et al.
Reist, E., et al. J. Organic Chemistry, vol. 32, 2538-2541 (1967).
Unger et al., Tetrahedron Letters, No. 50, pp. 4383-4384 (1977).

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