2-substituted amino and thio alkyl benzoxazine antimicrobial age

Details 2-substituted amino and thio alkyl benzoxazine antimicrobial age 2-substituted amino and thio alkyl benzoxazine antimicrobial age

1996-01-30

1998-01-13

Datlow, Philip I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544105, A61K 31535, C07D26536

Patent

active

057079900

ABSTRACT:
The invention relates to benzoxazine and pyrido-oxazine antibacterial compounds of the general formula: ##STR1## wherein the moiety Q is a fused phenyl or fused pyridyl moiety and R is a substituted amine or substituted thio moiety as herein described, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

REFERENCES:
M. J. Mahan, J. M. Slauch and J. J. Mekalanos, Science vol. 259, 686-688 (1993) Selection of Bacterial Virulence Genes that are Specifically Induced in Host Tissues.
S. Roychoudhury et al., Proc. Nat. Acad. Sci., vol. 90, 965-969 (1993) Inhibitors of Two-Component Signal Transduction Systems: Inhibition of Alginate Gene Activation in Pseudomonas Aeruginosa.
Kajino, Chemical Abstract 116:174105 for Chem. Pharm. Bull, 39(11), 2896-905 (1991).
Meguro, Chem. Abstract 108:37848 for EP-233,728 (Aug. 26, 1987).
Masuoka et al, Chem. Pharm. Bull, 34(1), pp. 130-139 (1986).

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