2-(substituted amino) adenosines as antihypertensives

Details 2-(substituted amino) adenosines as antihypertensives 2-(substituted amino) adenosines as antihypertensives

1988-05-13

1991-07-23

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 536 26, 536 24, A61K 3170, C07H 19167

Patent

active

050343815

ABSTRACT:
Disclosed are 2-substituted adenosine derivatives of the formula ##STR1## in which R represents a substituted amino grouping of the formula ##STR2## as defined herein; pharmaceutically acceptable ester derivatives thereof in which free hydroxy groups are esterified in the form of a pharmaceutically acceptable prodrug ester; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for their preparation; and their use in mammals as therapeutically effective adenosine-2 (A-2) agonists.

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