2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardio

Details 2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardio 2-Substituted amino-5-(pyridinyl)-nicotinamides and their cardio

1981-08-17

1983-02-15

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546257, C07D40104, A61K 31455

Patent

active

043741410

ABSTRACT:
Shown is a process for preparing cardiotonically active 1,3-dihydro-3-R-6-PY-5-Q-2H-imidazo[4,5-b]pyridin-2-ones, where Q is hydrogen or lower-alkyl, R is lower-alkyl, lower-hydroxyalkyl, lower-alkoxyalkyl or Y-NB where Y is lower-alkylene and NB is di-(lower-alkyl)amino or 4-morpholinyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two substituents, by reacting a 2-RNH-5-PY-6-Q-nicotinamide with an alkali metal hypohalite. Also shown are cardiotonic compositions and a method for increasing cardiac contractility using 2-RR'N-5-PY-6-Q-nicotinamides or pharmaceutically acceptable acid-addition salts thereof, where R' is hydrogen or methyl. Also shown is the process for preparing said 2-RR'N-5-PY-6-Q-nicotinamides by reacting a 2-halo-5-PY-6-Q-nicotinamide with an amine of the formula RR'NH.

REFERENCES:
patent: 4107315 (1978-08-01), Lesher et al.
patent: 4264603 (1981-04-01), Lesher et al.
patent: 4264612 (1981-04-01), Lesher et al.
patent: 4297360 (1981-10-01), Lesher et al.
Baldwin et al., J. Med. Chem. 20, 1189-1193, (1977).

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