2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidi

Details 2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidi 2-substituted amino-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidi

1993-03-10

1994-02-08

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23902, A61K 31505

Patent

active

052849490

ABSTRACT:
The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are described as having activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.

REFERENCES:
patent: 4711888 (1987-12-01), Walker et al.
patent: 4859679 (1989-08-01), Santini
patent: 4940712 (1990-07-01), Walker et al.
Lamattina et al, Tetrahedron Letters, vol. 25, No. 28, pp. 2957-2960 (1984).
Biochem., 1951, 48, pp. 400-406, Bray, et al.

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