2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimi

Details 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimi 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimi

1992-11-16

1993-06-15

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23902

Patent

active

052200256

ABSTRACT:
The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are described as having activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.

REFERENCES:
patent: 4554276 (1985-11-01), La Mattina
patent: 4711888 (1987-12-01), Walker et al.
patent: 4859679 (1989-08-01), Santini
patent: 4940712 (1990-07-01), Walker et al.
Bioch. J. 1951, 48, pp. 400-406.

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