2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrim

Details 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrim 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrim

1992-02-24

1993-03-23

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544295, 544246, 544298, C07D40300, C07D23902

Patent

active

051964317

ABSTRACT:
The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are described as having activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.

REFERENCES:
patent: 4711888 (1987-12-01), Walker et al.
patent: 4859679 (1989-08-01), Santini
patent: 4940712 (1990-07-01), Walker et al.
Copending U.S. Application Ser. No. PCT/US92/00443 of Jan. 17, 1992.
Bioch. J. 1951, 48, pp. 400-406.

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