2-substituted alkyl-3-carboxy carbopenems as antibiotics and a m

Details 2-substituted alkyl-3-carboxy carbopenems as antibiotics and a m 2-substituted alkyl-3-carboxy carbopenems as antibiotics and a m

1993-07-06

1994-11-29

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540302, C07D48704, A61K 3140

Patent

active

053691024

ABSTRACT:
The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: ##STR1## with R.sup.1, R.sup.2, R.sup.3, X and Y defined hereafter as antibiotics and beta lactamase inhibitors produced by a novel Michael addition-elimination reaction of a substituted allyl azetidinone in the reaction shown: ##STR2## with R.sup.1, R.sup.2, Q, X and Y defined hereafter.

REFERENCES:
patent: 4845210 (1989-07-01), Nakai
patent: 5021565 (1991-06-01), Ratcliffe
Chemical Abstracts, vol. 99 No. 17, 24th Oct. 1983, p. 572, abstract No. 139645b & JP-A-58 103 388.
Chemical Abstracts, vol. 104, No. 1, 6th Jan. 1986, p. 516, abstract No. 5672w, and Heterocycles 1985, 23(8), 1915-19.
Tetrahedron Letters, vol. 28, No. 25, 1987, pp. 2887-2888.

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