2-substituted alkyl-3-carboxy carbapenems as antibiotics and a m

Details 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a m 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a m

1994-04-28

1996-01-02

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20508, C07F 718, A61K 3140

Patent

active

054809878

ABSTRACT:
The invention provides substituted allylazetidinone compounds having the formula: ##STR1## and propargyl azetidinone compounds having the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.30, X, Y and Q are defined in the specification.

REFERENCES:
patent: 4350631 (1982-09-01), Christensen
patent: 4377591 (1983-03-01), Hiraoka
patent: 4845210 (1989-07-01), Nakai
J. Tsuji, Tetrahedron Letters (1980), vol. 21 pp. 849-850.
H. Hofmeister, Ang. Chem. Int. Ed. Engl. (1984) vol. 23 pp. 727-728.
K. Hartke, Tetrahedron Letters (1989), vol. 30, No. 9, pp. 1073-1076.
T. Kobayashi, Chemistry Letters (1987) pp. 1209-1212.
R. F. Newton, Tetrahedron Letters (1979), No. 41, pp. 3981-3982.
R. N. Guthikonda, J. Med. Chem. (1978), vol. 30 pp. 871-880.
T. N. Salzmann, "Recent Advances In The Chemistry Of Bata-Lactam Antibiotics", 1989 pp. 171-189.
de Vries, Tetrahedron Letters, vol. 25, No. 52 pp. 5989-5992 (1984).
de Vries, Heterocycles, vol. 23, No. 8 pp. 1915-1919 (1985).
T. W. Greene, "Protective Groups In Organic Synthesis", 1981 pp. 88-101, 223-249, 195-213.
A. Hassner, Tetrahedron Letters, No. 46, pp. 4475-4478.
W. E. Truce, J. Organic Chemistry 1971, col. 36, No. 13, pp. 1727-1731.
S. Patai, "The Chemistry Of The Carbon-Carbon Triple Bond", J. Wiley (1978) pp. 320-327.
S. Uemura, J. Chem. Soc. Chem. Commun. (19750 pp. 925-926.
L. Brandsma, "Preparative Acetylenic Chemistry", Elsevier (1988) Chapter 8.
J. March, "Advanced Organic Chemistry", J. Wiley, 3rd Ed (1985) pp. 295-296.
M. Ohtani, "Mild Deprotection Of Carbapenm Esters With Aluminum Trichlorids", J. Organic Chem (1984), 49, 5271-5272.
Chemical Abstracts, vol. 99 No. 17, 24th Oct. 1983, p. 572, abstract No. 139645b & JP-A-58 103 388.
Chemical Abstracts, vol. 104, No. 1, 6th Jan. 1986, p. 516, abstract No. 5672w, and Heterocycles 1985, 23(8), 1915-19.
Tetrahedron Letters, vol. 28, No. 25, 1987, pp. 2887-2888.

Affiliated with

Also associated with

Rating

2-substituted alkyl-3-carboxy carbapenems as antibiotics and a m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a m will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-236169