2-substituted alkoxy-3-substituted-pyrazines

Details 2-substituted alkoxy-3-substituted-pyrazines 2-substituted alkoxy-3-substituted-pyrazines

1987-06-30

1990-01-16

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544116, 544357, 544408, 540575, C07D24138, C07D24118, C07D40312

Patent

active

048944530

ABSTRACT:
A compound of the formula ##STR1## wherein Q is --CO-- or --CH.sub.2 --, R is hydroxyl, lower alkoxy, halogen, --NH-lower alkylene-OH, --NH-lower alkylene-arylthio, --NH-lower alkylene-halogen, ##STR2## in which ##STR3## is dilower alkylamino, cycloalkylamino, morpholino, ##STR4## in which R.sub.9 is hydrogen, lower alkyl or aryl, R.sub.10 is hydrogen, lower alkyl, hydroxy-lower alkyl, hydroxy-lower alkoxy-lower alkyl or di(aryl)-lower alkyl, m is an integer from 4 to 6, n is 2 or 3, R.sub.1 is alkyl or aryl-lower alkyl, R.sub.2 and R.sub.3 are each lower alkyl, or together form tetramethylene, and R.sub.4 is hydrogen, lower alkyl or aryl, in which aryl is phenyl which is optionally substituted with a group selected from the group consisting of 1-3 halogen, nitro, lower alkyl and lower alkoxy, or a pharmaceutically acceptable salt thereof, inhibits blood platelet aggregation, has vasodilating activity and inhibits lipoperoxide generation.

REFERENCES:
patent: 3787411 (1974-01-01), Ruschis
patent: 4560756 (1985-12-01), Brunnmueller
"Abstracts of Papers 16th Congress of Heterocyclic Chemistry", Osaka, Japan, 1984, pp. 65-68.
"Pyrazine Derivatives", Chemical Abstracts, vol. 102, No. 25, Jun. 1985, Abstract No. 220898p, p. 597.

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