Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-09-15
1995-06-20
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 2761, C07H 19167, A61K 3170
Patent
active
054261015
ABSTRACT:
The compound (R)-2-[(phenylisopropyl)amino]adenosine whose structure is given below: ##STR1## (R)-2-[(phenylisopropyl)amino]adenosine is about two orders of magnitude greater in its selectivity between the A-1 and A-2 adenosine receptors than its diastereoisomer. This compound is useful for lowering blood pressure.
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Francis, J. E., "Highly Selective Adenosine A2 Receptor Agonists in a Series of N-Alkylated 2-Aminoadenosines", J. Med. Chem. 34:2570-2579, 1991.
Borcherding David R.
Kastner Philip R.
Lentz Nelsen L.
Peet Norton P.
Weintraub Philip M.
Kunz Gary L.
Lentz Nelsen L.
Merrell Dow Pharmaceuticals Inc.
Robinson Douglas W.
Sayles Michael J.
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