2-substituted adenosine derivatives and pharmaceutical compositi

Details 2-substituted adenosine derivatives and pharmaceutical compositi 2-substituted adenosine derivatives and pharmaceutical compositi

1991-11-27

1993-02-23

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 276, 536 273, 536 267, C07H 19167, A61K 3170

Patent

active

051890275

ABSTRACT:
Disclosed herein are a novel 2-substituted adenosine derivative having the following formula [I] ##STR1## wherein R represents a hydrogen atom or a hydroxyl group, m is an integer of 2 to 7, n is 0 or an integer of 1 to 3, and R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each independently represent a hydrogen atom, a hydroxy protective group or a phosphoric acid residue, and salts thereof.
The above compounds are excellent in a circulation ameliorating effect such as a vasodepressor activity, and have high selectivity for A.sub.2 receptors, but cause less undesirable side effects such as a suppresssive effect on the heart. They are therefore effective when used in pharmaceutical compositions for circulatory diseases.

REFERENCES:
patent: 4956345 (1990-09-01), Miyasaka et al.
patent: 4992427 (1991-02-01), Nair
Matsuda et al., Nucl. Acids Res. Symp. Ser., 16, 97-100 (1985).
Matsuda et al., Nucl. Acids Res. Symp. Ser., 12, 5-8 (1983).
Matsuda et al., Chem. Pharm. Bull., 33(4), 1766-1769 (1985).
Nair et al., "Copper Mediated Reactions in Nucleoside Synthesis, " Tett. Lett., 31(6), 807-810 (1990).

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