2-substituted-5-substituted-1,3-oxathiolanes with antiviral prop

Details 2-substituted-5-substituted-1,3-oxathiolanes with antiviral prop 2-substituted-5-substituted-1,3-oxathiolanes with antiviral prop

1991-06-17

1992-09-29

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514261, 514272, 514274, 514258, 544265, 544276, 544277, 544278, 544310, 544317, 544313, C07D23902, C07D47300, C07D49500, A61K 3152, A61K 31505

Patent

active

051514265

ABSTRACT:
Methods and compositions for preventing or treating human immunodeficiency virus (HIV) infections characterized by 2-substituted-5-substituted-1,3-oxathiolanes.

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Baba et al., "Both 2',3'-Dideoxythymidine and its 2',3'-Unsaturated Derivative (2',3'-Dideoxythymidinene) are Potent and Selective Inihibitors of Human Immunodeficiency Virus Replication in vitro", Biochemical and Biophysical Research Communications, 142(1) pp. 128-134 (1987).
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Huryn et al., "Synthesis of Iso-ddA, Member Of A Novel Class Of Anti-HIV Agents-Dioxolane-T, A New 2',3,-Dideoxynucleoside Prototype With In Vitro Activity Against HIV", Chemtracts-Organic Chemistry 3, pp. 249-251 (1990).
Mitsuya et al., "3'-Azido-3'-Deoxythymidine (BW A509U): An Antiviral Agent that Inhibits the Infectivity and Cytopathic Effect of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus in vitro", Proc. Natl. Acad. Sci. USA, 82, pp. 7096-7100 (1986).
Gosselin et al., "Systematic Synthesis And Biological Evaluation Of .alpha.- and .beta.-D-Lyxofuranosyl Nucleosides Of The Five naturally Occurring Nucleic Acid Bases", J. Med. Chem., 30, pp. 982-991 (1987).
Herdewijn et al., "3'-Substituted 2',3'-Dideoxynucleoside Analogues as Potential Anti-HIV (HTLV-III/LAV) Agents", J. Med. Chem., 30, pp. 1270-1278 (1987).
Carlisle et al., "Cellular Pharmacology Of The Anti-HIV Agent BCH-189 (2'-Deoxy-3'-Thiacytidine) In Human Peripheral Blood Mononuclear Cells (PBMC)", American Association for Cancer Research Proceedings, 31, abstract 2435, (1990).
Belleau et al., "Design And Activity Of A Novel Class OF Nucleoside Analogs Effective Against HIV-1", Fifth International Conference on AIDS, Montreal, Canada, Abstraact T.C.O. 1 (1989).

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