2-substituted-5-substituted-1,3-oxathiolanes with antiviral prop

Details 2-substituted-5-substituted-1,3-oxathiolanes with antiviral prop 2-substituted-5-substituted-1,3-oxathiolanes with antiviral prop

1989-02-08

1991-09-10

Rivers, Diana G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514262, 514266, 544212, 544276, 544277, 544313, 544314, 544317, A61K 31505, C07D41104

Patent

active

050474073

ABSTRACT:
Methods and compositions for preventing or treating human immunodeficiency virus (HIV) infections characterized by 2-substituted-5-substituted-1,3-oxathiolanes.

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patent: 4415573 (1983-11-01), Ochi et al.
Mitsuya et al., "3'-Azido-3'-Deoxythmidine (BW A509U): An Antiviral Agent that Inhibits the Infectivity and Cytophatic Effect of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus In Vitro", Proc. Natl. Acad. Sci. USA, 82, pp. 7096-7100 (1986).
Mitsuya et al., "Inhibition of the In Vitro Infectivity and Cytophatic Effect of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus (HTLV-III/LAV) BY 2',3'-Dideoxynucleosides", Proc. Natl. Acad. Sci. USA, 83, pp. 1911-1915 (1986).
Balzarini et al., "Potent and Selective Anti-HTLV-III/LAV Activity of 2',3'-Dideoxycytidinene, The 2',3'-Unsaturated Derivative of 2',3'-Dideoxycytidine", Biochemical and Biophysical Research Communications, 140(2), pp. 735-742 (1986).
Baba et al., "Both 2',3'-Dideoxythymidine and Its 2',3'-Unsaturated Derivative (2',3'-Dideoxythymidinene) Are Potent and Selective Inhibitors of Human Immunoefficiency Virus Replication In Vitro", Biochemical and Biophysicals Research Communications, 142(1), pp. 128-134 (1987).
Lin et al., "Synthesis and Antiviral Activity of Various 3'-Azido, 3'-Amino 2',3'-Unsaturated and 2',3'-Dideoxy Analogues of Pyrimidine Deoxyribonucleosides Against Retroviruses", J. Med. Chem., 30, pp. 440-444 (1987).
Herdewijn et al., "3'-Substituted 2',3'-Dideoxynucleoside Analogues as Potential Anti-HIV (HTLV-III/LAV) Agents", J. Med. Chem., 30, pp. 1270-1278 (1987).
Hallonquist et al., "Studies on Reactions Relating to Carbohydrates and Polysaccharides", Canadian Journal of Research, 7, pp. 129-136 (1933).

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