2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, the salts and

Details 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, the salts and 2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes, the salts and

1975-03-24

1977-04-26

Myers, Jane S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472B, 260253, 260268R, 26029362, 260309, 2603096, 26032633, 260429R, 2604299, 2604381, 260439R, 260448R, 260471R, 260473R, 2605011, 26050111, 26050113, 26050115, 26050117, 2605012, 260515R, 424230, 424310, 424316, 42424855, 424317, 424250, 424253, 424267, 424273, 424274, 424287, 424289, 424295, 424308, C07C 6520, C07C 6995

Patent

active

040200949

ABSTRACT:
2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where R' is hydrogen, alkyl having 1 to 12 carbon atoms, or ##STR2## where n is an integer from 2 to 4, inclusive, and R.sup.4 and R.sup.5 are independently lower alkyl having 1 to 6 carbon atoms or together R.sup.4 and R.sup.5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 or 6 total ring atoms; one of R.sup.2 and R.sup.3 is hydrogen and the other is hydrogen, methyl, or ethyl, or together R.sup.2 and R.sup.3 are methylene; and the pharmaceutically acceptable salts thereof. The compounds have anti-inflammatory, analgesic, and antipyretic activities and, accordingly, are useful in the treatment of inflammation, pain and/or pyrexia.

REFERENCES:
patent: 3256335 (1966-06-01), Slates et al.
patent: 3468939 (1969-09-01), Kaltenbronn
patent: 3600437 (1971-08-01), Marshall
patent: 3624142 (1971-11-01), Shen et al.
patent: 3641134 (1972-02-01), Shen et al.
patent: 3780061 (1973-12-01), Allais et al.
patent: 3803234 (1974-04-01), Dostert et al.
patent: 3933905 (1976-01-01), Brunet et al.

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