2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines use

Details 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines use 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines use

1991-01-31

1993-01-05

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514241, 514242, 514252, 544182, 544298, 544238, 544295, 544333, A61K 31505, C07D23902, C07D40104, C07D40106

Patent

active

051770792

ABSTRACT:
The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenease and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.

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