2-Substituted-3-methyl-.gamma.-pyrone tricvclic derivatives and

Details 2-Substituted-3-methyl-.gamma.-pyrone tricvclic derivatives and 2-Substituted-3-methyl-.gamma.-pyrone tricvclic derivatives and

1977-11-28

1979-12-04

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

424269, 548253, 549 26, 549 27, 2603452, A61K 3138, C07D49504

Patent

active

041772849

ABSTRACT:
Compounds of formula I ##STR1## in which R.sup.1 is hydrogen, halogen, nitro, trifluoromethyl, lower alkyl or lower alkoxy; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydroxy, 1H-tetrazol-5-yl or COOR.sup.4 wherein R.sup.4 is hydrogen or lower alkyl, and X is O, S, SO or SO.sub.2, are disclosed. The compounds of formula I are useful for treating allergic conditions. Methods for the preparation and use of the compounds are disclosed.

REFERENCES:
patent: 3816467 (1974-06-01), Wright
patent: 3855216 (1974-12-01), Kaminsky et al.
patent: 3862144 (1975-01-01), Kaminsky
patent: 4060619 (1977-11-01), Philipp et al.
Dean et al., J. Chem. Soc., Chem. Comm., (1974), pp. 440-441.

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