2-substituted-1-naphthols, pharmaceutical compositions of, and t

Details 2-substituted-1-naphthols, pharmaceutical compositions of, and t 2-substituted-1-naphthols, pharmaceutical compositions of, and t

1986-03-19

1989-05-23

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

568 27, 568 28, 568 31, 568 38, 568 63, 568 64, 568736, 568737, 564 84, 564 92, 564180, 564315, 560 17, 560100, 560255, 579 78, 579497, 548186, 548235, 548341, 548551, 546189, 546344, 540484, 514319, 514429, 514510, 514706, 514708, 514712, 514717, 514732, 514885, C07C 3914, A61K 31045

Patent

active

048331643

ABSTRACT:
2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung diseases and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkenyls, the groups CH.sub.2 --C.tbd.C--(CH.sub.2).sub.m R.sup.5 and CH.dbd.CH--(CH.sub.2).sub.n R.sup.5 (where m is 1-4, n is 0-3 and R.sup.5 includes phenyl, COOR.sup.9, where R.sup.9 is H or alkyl of 1-4 carbons, AR.sup.6 (where A is a methylene chain and R.sup.6 is a variety of groups including Cl, Br, I, CHO, CN, COOR.sup.9, NH.sub.2, SC(NH)NH.sub.2, phenyl, P(O)(OR.sup.9).sub.2, etc.), and CHR.sup.7 R.sup.21 (where R.sup.7 is a variety of aromatic and heterocyclic groups and R.sup.21 is H, optionally substituted phenyl and a variety of heterocyclic groups).

REFERENCES:
patent: 3761526 (1973-09-01), Houlihan et al.
patent: 4466981 (1984-08-01), Jones et al.
Chemische Berichte, vol. 114, No. 3, 1981, pp. 1091-1098, Verlag Chemie, Weinheim, DE; F. Bohlmann et al.
Bagavant, G. et al., Indian Journal of Pharmaceutical Sciences, 1985, 47, pp. 12-15.

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