2-substituted-1-naphthols as 5-lipoxygenase inhibitors

Details 2-substituted-1-naphthols as 5-lipoxygenase inhibitors 2-substituted-1-naphthols as 5-lipoxygenase inhibitors

1989-03-16

1991-01-15

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 514732, 546189, 548539, A61K 31435, C07D21132, C07D20704

Patent

active

049854356

ABSTRACT:
2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung diseases and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkenyls, the groups CH.sub.2 --C.tbd.C--(CH.sub.2).sub.m R.sup.5 and CH.dbd.CH--(CH.sub.2).sub.n R.sup.5 (where m is 1-4, n is 0-3 and R.sup.5 includes phenyl, COOR.sup.9, where R.sup.9 is H or alkyl of 1-4 carbons, AR.sup.6 l (where A is a methylene chain and R.sup.6 is a variety of groups including Cl, Br, I, CHO, CN, COOR.sup.9, NH.sub.2, SC(NH)NH.sub.2, phenyl, P(O)(OR.sup.9).sub.2, etc.), and CHR.sup.7 R.sup.21 (where R.sup.7 is a variety of aromatic and heterocyclic groups and R.sup.21 is H, optionally substituted phenyl and a variety of heterocyclic groups).

REFERENCES:
patent: 4737519 (1989-04-01), Yamashita et al.
patent: 4833164 (1989-05-01), Batt
Hassner, A., "The Chemistry of Derivatives of Benzaltetralone".
J. Am. Chem. Soc. 80, 893-900 (1958).
Chemical Abstracts, (63), 9891a, Zenichi Horii, Takefumi Momose, and Yasumitsu Tamnra.

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