2-substituted -1,4-dihydropyridines and pharmaceutical compositi

Details 2-substituted -1,4-dihydropyridines and pharmaceutical compositi 2-substituted -1,4-dihydropyridines and pharmaceutical compositi

1986-07-25

1989-07-04

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544365, 544131, 544405, 514352, 546193, 546194, 546256, 546257, 546263, 546270, 546278, 546281, 546283, 546284, 546286, 546310, 546316, 546321, 546322, C07D21186, A61K 31455

Patent

active

048451134

ABSTRACT:
Compounds of formula I ##STR1## wherein R is hydrogen or lower alkyl; R.sub.1 is acetyl, benzoyl, cyano, nitro, carboxy, alkoxycarbonyl or aminocarbonyl groups; R.sub.2 is an optionally substituted aryl or hetaryl residue; R.sub.3 is a carboxy or alkoxycarbonyl group; A is a cyclopropyl group or a group of formula --CH.dbd.CH-- and R.sub.4 is a phenyl or heteroaryl group, optionally mono, di or tri-substituted, are useful in radical scavenging therapy.

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