2-Substitute d-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,

Details 2-Substitute d-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4, 2-Substitute d-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,

1979-01-23

1980-09-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 85, 2603478, A61K 31445, C07D47104

Patent

active

042243297

ABSTRACT:
2-Substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles of the formula (I): ##STR1## and the pharmaceutically-acceptable salts thereof, wherein the hydrogen atoms in the 4a position and 9b positions are in a trans relationship to each other and the 5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole moiety is dextrorotatory; X.sub.1 and Y.sub.1 are the same or different and are each hydrogen or fluoro; Z.sub.1 is hydrogen, fluoro or methoxy; M is a member selected from the group consisting of ##STR2## a mixture thereof and C.dbd.O and n is 3 or 4; their use as tranquilizing agents, pharmaceutical compositions containing them and a process for their production.

REFERENCES:
patent: 3382250 (1968-05-01), Johnson et al.
patent: 3687961 (1972-08-01), Bernstein et al.
patent: 3983239 (1976-09-01), Nagai et al.
patent: 3991199 (1976-11-01), Berger
patent: 4001263 (1977-01-01), Plattner et al.
patent: 4141980 (1979-02-01), Berger
Colonge et al., Bull. Soc. Chim. France 1966, pp. 2005-2011. _

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