Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-04-08
1993-11-23
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514202, 540222, 540225, 540226, C07D50120, A61K 31545
Patent
active
052644308
ABSTRACT:
Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula I ##STR1## are provided which are useful as potent elastase inhibitors.
REFERENCES:
patent: 3883517 (1975-05-01), Heusler et al.
patent: 4547371 (1985-10-01), Doherty et al.
"Inhibition of Human Leukocyte Elastase". 4. Selection of a Substitute Cephalosporin (L-658,758) as a Topical Aerosol, J. Med. Chem, vol. 35, pp. 3731-3744 (1992).
Alpagiani et al., Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 9, pp. 1127-1132, 1992.
Doherty et al, "Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase", Nature, 322, 192-194 (Jul. 10, 1986).
Pitlick et al, J. Heterocyclic Chem., 26, 461-464, (1989).
Adachi Kazuo
Czajkowski David
Maiti Samarendra N.
Micetich Ronald G.
Spevak Paul
Rizzo Nicholas S.
SynPhar Laboratories, Inc.
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