2'-(R)-substituted-2'-deoxyneplanocin A derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544276, C07D47330, A61K 3152

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active

048165751

ABSTRACT:
Neplanocin A derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen or benzoyl, R.sub.4 is hydrogen or halogen, hydroxy, acetoxy, acetylthio, amino or azide, R.sub.5 is hydrogen or acetyl, and R.sub.6 is hydrogen or acetyl. The compounds of the present invention have inhibitory action for the growth of L 5178 Y cells and have the same or superior activity as neplanocin A.

REFERENCES:
patent: 4138562 (1979-02-01), Vince
patent: 4423218 (1983-12-01), Otani et al.
patent: 4613666 (1986-09-01), Fukikawa et al.

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