2-pyrrolidone derivatives as prostanoid agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S550000, C548S551000

Reexamination Certificate

active

06849657

ABSTRACT:
This invention relates to 8-aza prostanoid analogs which are generally EP4receptor agonists and are represented by Formula I:wherein Q, B, X, J, Z, A and R1-R6are as defined, their synthesis and use for treatment of osteoporosis and increasing bone density.

REFERENCES:
patent: 3975399 (1976-08-01), DeFranco et al.
patent: 4113873 (1978-09-01), Himizu et al.
patent: 4115401 (1978-09-01), Nanthavong et al.
patent: 4177346 (1979-12-01), Nelson
patent: 4320136 (1982-03-01), Scribner
patent: 6211226 (2001-04-01), Hellberg et al.
patent: 841165 (1976-10-01), None
patent: 1 097 922 (2001-05-01), None
patent: 1 132 086 (2001-09-01), None
patent: 1553595 (1979-10-01), None
patent: 1569982 (1980-06-01), None
patent: 1583163 (1981-01-01), None
patent: WO 99 02164 (1999-01-01), None
patent: WO 0021532 (2000-04-01), None
patent: WO 0021542 (2000-04-01), None
patent: WO 0146140 (2001-06-01), None
patent: WO 01 62724 (2001-08-01), None
patent: WO 0224647 (2002-03-01), None
patent: WO 0242268 (2002-05-01), None
Zoretic et al., “Synthesis of (E)-7-[[2-[4(m-Trifluoromethylphenoxy)-3α and 3β-Hydroxy-1-butenyl]-5-oxo-1-pyrrolidinyl]]heptanoic Acids”,J. Heterocyclic Chem., Mar.-Apr. 1983, pp. 465-466, 20.
Saijo, et al., “Heterocyclic prostaglandins. IV. Synthesis of 8-aza-11-deoxyprostaglandin E1and its related compounds,”Yakugaku Zashi, 1980, pp. 389-395, 100(4), AbstractCA 93:204109x.
Suda, et al., “Prostaglandin E Receptor Subtypes in Mouse Osteoblastic Cell Line,”Endocrinology, 1996, pp. 1698-1705, 137, No. 5.
Suzawa, et al., “The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPs,”Endocrinology, 2000, pp. 1554-1559, 141(4).
Ono, et al., “Important role of EP4, a subtype of prostaglandin (PG) E receptor, in osteoclast-like cell formation from mouse bone marrow cells induced by PGE2,”Journal of Endocrinology, 1998, pp. R1-R5, 158.
Hazato, et al., “Synthesis of Thiaprostaglandin E1Derivatives,”Chem. Pharm. Bull., 1985, pp. 1815-1825, vol. 33(5).

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