2-Pyridylcarboxamides which inhibit arachidonic acid release

Details 2-Pyridylcarboxamides which inhibit arachidonic acid release 2-Pyridylcarboxamides which inhibit arachidonic acid release

1984-08-20

1985-11-26

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514354, 546291, 546323, C07D21381, A61K 31455

Patent

active

045555206

ABSTRACT:
2-Pyridylcarboxamides are provided having the structure ##STR1## wherein n is 1 to 10; R is hydrogen, lower alkyl, alkali metal or an amine salt; and

REFERENCES:
Bach; M. K., "Prospects for the Inhibition of Leukotriene Synthesis," Biochemical Pharmacology, vol. 33, No. 4, pp. 512-521, (1984).
Samuelsson; B., "Leukotrienes: Mediators of Immediate Hypersensitivity Reaction and Inflammation", Science, vol. 220, pp. 568-575, (1983).
Samuelsson; B., "The Leukotrienes, Highly Biologically Active Substances Involved in Allergy and Inflammation", Angew Chem. Int. Ed. Engl., 21 (1982), pp. 902-910.
Ford-Hutchinson; A. W., "Leukotriene Involvement in Pathologic Processes", J. Allergy Clin. Immunol., Sep. 1984.
Kuehl; F. A., et al., "Interactions Between Prostaglandins and Leukotrienes", Biochemical Pharmacology, vol. 33, No. 1, pp. 1-5, (1984).

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