2-pyridylacetic acid derivative, and pharmaceutical composition

Details 2-pyridylacetic acid derivative, and pharmaceutical composition 2-pyridylacetic acid derivative, and pharmaceutical composition

1988-03-03

1989-06-27

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546267, 546193, 546194, 546331, 514332, 514357, C07D21355, C07D40106, A61K 31445

Patent

active

048430838

ABSTRACT:
A 2-pyridylacetic acid derivative having the formula (I): ##STR1## wherein R.sup.1 represents an alkyl having 5 to 10 carbon atom or --(CH.sub.2).sub.m --cycloalkyl group having C.sub.5 -C.sub.8 cycloalkyl, which may be substituted with at least one alkyl group having 1 to 6 carbon atoms, where m represents zero or an integer of 1 to 4; R.sup.2 represents hydrogen, a linear alkyl, a hydroxyalkyl group, an alkenyl, an aryl, an aralkyl or a group--(CH.sub.2)--A, where n represents an integer of 0 to 3 and A represents a nitrogen-containing heterocyclic group which may be replaced by an alkyl having 1 to 10 carbon atoms or an aralkyl having 7 to 10 carbon atoms and a pharmacologically acceptable acid addition salt thereof, which has the effects of both an inhibition of gastric acid and a protection of gastric mucosa, and which has a low toxicity.

REFERENCES:
patent: 4738977 (1988-04-01), Okitsu
Smith, The Chemistry of Open-Chain Organic Nitrogen Compounds, vol. 1, pp. 29-30, Benjamin, pub. 1965.
March, Advanced Organic Chemistry, Reactions, Mechanisms, and Structure, Second Edition, p. 386, McGraw-Hill, 1979.

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