2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as

Details 2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as 2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as

1981-02-02

1983-01-18

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424266, 546270, A61K 3144, A61K 31455, C07D41704

Patent

active

043691838

ABSTRACT:
The invention concerns novel 2-aryl-1,2-benzisothiazolinone-1,1-dioxide compounds; methods for their preparation; pharmaceutical compositions containing them as an active ingredient; and methods of selectively inhibiting proteases, especially elastase, and of treating emphysema, rheumatoid arthritis, and various inflammatory diseases, for example, bronchial inflammation.

REFERENCES:
patent: 4006007 (1977-02-01), Bollinger
Rasshofer et al., Chem. Abst. 1979, vol. 91, No. 157557p.
Rasshofer et al., Chem. Abst. 1980, vol. 93, No. 132456h.
Fischer et al., Arzneimittel Forschung, 1964, vol. 14 (12), p. 1301.
Stroud, Scientific American, Jul. 1974, pp. 74-88.

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