2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A deriv

Details 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A deriv 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A deriv

1996-04-02

1998-02-17

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 72, 536 185, 536 186, C07H 100, C07H 1708

Patent

active

057192723

ABSTRACT:
A process of preparing a 6-O-methyl erythromycin A derivative using a 2'-protected, 9-etheroxime erythromycin A intermediate is provided. A preferred protecting group for the 2'-position is acetyl. 2'-protected, 9-etheroxime erythromycin A derivatives are also provided. Also disclosed is a method for inhibiting quaternary salt formation at the 3' amine without the need for 3'N-protecting groups.

REFERENCES:
patent: 4670549 (1987-06-01), Mormoto et al.
patent: 5350839 (1994-09-01), Asaka et al.

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