2-piperidino-1-alkanol derivatives as antiischemic agents

Details 2-piperidino-1-alkanol derivatives as antiischemic agents 2-piperidino-1-alkanol derivatives as antiischemic agents

1992-08-20

1993-12-21

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546216, 546217, A61K 31445, C07D21148, C07D21152

Patent

active

052721604

ABSTRACT:
2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula ##STR1## wherein Q is S or CH.dbd.CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y.sup.1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and Y.sup.1 are taken separately and Y is hydrogen or OH, and Y.sup.1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.

REFERENCES:
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patent: 3509164 (1970-04-01), Carron et al.
patent: 4393069 (1983-07-01), Langbein et al.
Carron, et al., Arzneim-Forsch. (Drug Res.), 21 1992-9 (1971).
Carter, et al., Journal of Pharmacology and Experimental Therapeutics, 247, 1222-32 (1988).
Gotti, et al., Journal of Pharmacology & Experimental Therapeutics, 247, 1211-22 (1988).

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