2-piperidinecarboxylic acid derivatives useful as NMDA receptor

Details 2-piperidinecarboxylic acid derivatives useful as NMDA receptor 2-piperidinecarboxylic acid derivatives useful as NMDA receptor

1992-10-16

1993-11-09

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

546 22, C07F 906, C07F 938, A61K 31675

Patent

active

052602869

ABSTRACT:
Compounds of formula I ##STR1## wherein X is ##STR2## or .dbd.N--O--, in which R.sub.4 is hydrogen or halogen, R.sub.1, R.sub.2, and R.sub.3 independently represent hydrogen or a C.sub.1-4 alkyl group, and n has a value of zero to four are disclosed. Also disclosed are pharmaceutically acceptable salts of these compounds, pharmaceutical compositions of these compounds or salts with a pharmaceutically acceptable carrier, the use of these materials as N-methyl-D-aspartate receptor antagonists, processes for preparing these compounds and salts, and methods to treat cerebral diseases by administering an effective amount of these compounds, salts or compositions.

REFERENCES:
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patent: 4746653 (1988-05-01), Hutchinson et al.
patent: 4837226 (1989-06-01), Coughenour et al.
patent: 4898854 (1990-02-01), Hutchinson et al.
patent: 4906621 (1990-03-01), Hutchinson et al.
patent: 4916125 (1990-04-01), Herrling et al.

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