2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl) benz

Details 2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl) benz 2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl) benz

1996-08-27

1998-01-13

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 546196, 546269, A61K 31445, A61K 3144, C07D40504

Patent

active

057080070

ABSTRACT:
These are disclosed novel 2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives of the formula ##STR1## where the substituents are as defined in the specification, which are useful as acetylcholinesterase inhibitors and as such may be useful for the treatment of Alzheimer's disease and other senile dementias.

REFERENCES:
patent: 4210655 (1980-07-01), Schenker
patent: 4600719 (1986-07-01), Schenker
Schenker et al. Chemical Abstract, (72063d) vol. 90, 1979.
Wyngaarden, et al., Textbook of Medicine,. p. 39 (1983).
Wilbraham, et al. Organic and Biological Chemistry, South IL Univ (Publisher) pp. 268-169.
Chen, et al. J. Med Chemistry, "Synethese, Resolution, and Structure-Activity of Potent Acetylcholinesterase Inhibitors 8-Carbaphysostigime Analogue", vol. 35, No. 8, pp. 1429-1434, 1992.
Stern, et a.l. Neurology, "Long-term Administration of oral physostigmine in Alzheimer's Disease", vol. 38, pp. 1837-1841m 1968.
Becker et al Drug Devel Res "Effects of Metrifonate, A Long-Acting Cholinesterase Inhibitor, in Alzheimer Disease: Report of an OpenTrial", 19:425-434, 1990.
Schenker et al "Piperidine Derivatives" CA 90:72063 (1979).
Wyngaarden et al "Cecil Textbook of Medicine" Saunders Co. p. 639 (1983).
Wilbraham et al "Organic and Biological Chemistry" South Ill. University (Publisher), pp. 268-269 (1985).

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