2-(Piperazinyl)-4-pyrimioinamines

Details 2-(Piperazinyl)-4-pyrimioinamines 2-(Piperazinyl)-4-pyrimioinamines

1980-04-18

1982-06-08

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602433, 544284, 544291, 544295, A61K 31505

Patent

active

043339379

ABSTRACT:
Herein is disclosed 2-(1-piperazinyl)-4-pyrimidinamine derivatives, acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are distinguished most readily by having novel substituents at position 4 of the piperazinyl radical, the substituents being selected from the group consisting of optionally substituted 2-cycloheptimidazolyl, 1,4,5,6,7,8-hexahydrocycloheptimidazol-2-yl, 2-benzoxazolyl, benzthiazol-2-yl, 1H-2-benzimidazolyl and 1-oxo-2,4,6-cycloheptarien-2-yl. The derivatives are useful for treating hypertension in a mammal.

REFERENCES:
patent: 3511836 (1970-05-01), Hess
patent: 3935213 (1976-01-01), Hess
patent: 4001237 (1977-01-01), Partyka et al.
patent: 4093726 (1978-06-01), Winn et al.
Althuis et al., J. Med. Chem., 20, 146-149 (1977).
Derwent Publications Ltd., Farmdoe 36461B for Netherland Patent 7,804,135.

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