2-Phosphonoxy-4-trifluoromethylbenzoic acid derivatives and phar

Details 2-Phosphonoxy-4-trifluoromethylbenzoic acid derivatives and phar 2-Phosphonoxy-4-trifluoromethylbenzoic acid derivatives and phar

1976-12-30

1978-08-29

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

260521H, 260941, 560130, 424311, 424317, A01N 936, C07F 909

Patent

active

041104420

ABSTRACT:
2-OR-4-trifluoromethylbenzoic acid wherein R is phosphonoxy.
The compounds are useful in the treatment of pathological cardiovascular conditions, particularly in the prophylaxis of the thromboembolic diseases.
The compounds are made by reacting m-trifluoromethyl phenol with potassium carbonate and carbon dioxide at an elevated temperature and pressure and, reacting the 2-OH compound with a phosphonating agent.
The invention also embraces pharmaceutical compositions in which the compounds constitute the effective agent and a method of treatment.

REFERENCES:
patent: 3019253 (1962-01-01), Hauptshein

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