2-phenylthiophene derivative

Details 2-phenylthiophene derivative 2-phenylthiophene derivative

2005-08-26

2009-11-03

Solola, Taofiq A (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S062000

Reexamination Certificate

active

07612108

ABSTRACT:
The present invention relates to a 2-phenylthiophene derivative or a salt thereof, wherein the thiophene ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.

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Noguchi et al., Synthesis and Structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents, Bioorganic & Medicinal Chemistry, 2003, vol. 11, No. 22, p. 4729-42.

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