2-[(Phenylthio)methyl or ethyl]pyridine derivatives

Details 2-[(Phenylthio)methyl or ethyl]pyridine derivatives 2-[(Phenylthio)methyl or ethyl]pyridine derivatives

1982-01-21

1983-07-19

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546301, 424263, C07D21332, C07D21344

Patent

active

043945090

ABSTRACT:
The invention provides a compound of formula I ##STR1## wherein R represents hydrogen, lower alkyl, phenyl, halophenyl, loweralkylphenyl, loweralkoxyphenyl or aralkyl of 7 to 12 carbon atoms, R.sup.1 represents hydrogen or fluorine, R.sup.2 represents hydrogen, fluorine, chlorine or trifluoromethyl, n is 1 or 2 or pharmaceutically acceptable acid addition salt thereof.
Pharmaceutical compositions containing the compounds are also covered as are methods of treating ulcers or hypersecretion using the compounds. Corresponding thiocompounds, useful as intermediates, are also disclosed.

REFERENCES:
patent: 2826584 (1958-03-01), Cislak
patent: 4038435 (1977-07-01), Winter et al.
patent: 4337259 (1982-06-01), Crossley
Bauer et al., Journal of Organic Chemistry, vol. 28, pp. 1323-1328, (1963).

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