2-phenylpropionic acid esters, method for optical resolution the

Details 2-phenylpropionic acid esters, method for optical resolution the 2-phenylpropionic acid esters, method for optical resolution the

1985-10-21

1987-11-24

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6976

Patent

active

047090820

ABSTRACT:
2-Phenylpropoionic acid ester of Formula (I): ##STR1## wherein R represents p-nitrophenyl group, .beta.-naphthyl group or 2-(.beta.-naphthyl)ethyl group.
Optical resolution of the above is carried out by preferential crystallization by seeding either one of the optical isomers into a super-saturated solution of a racemic modification thereof or a mixture of the optical isomers thereof. The efficiency of the optical resolution can be increased by optional addition of a recemizing agent comprising a strongly basic amine or an alcholate.

REFERENCES:
patent: 3641161 (1972-02-01), Fried et al.
patent: 4299844 (1981-11-01), Goudie
Brown, J. M., J.C.S. Chem. Comm. 1974, pp. 969-971.
Chemical Abstracts, 89, 1978, p. 726, 89: 107233q.
Chemical Abstracts Service Registry Handbook, 1975 Supplement 55019-71-1 & 55019-72-2.
Chem. Abstracts, 86, 1977, p. 475, 86:170527v.

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