2-phenylpropionic acid derivatives and pharmaceutical...

Details 2-phenylpropionic acid derivatives and pharmaceutical... 2-phenylpropionic acid derivatives and pharmaceutical...

2005-03-21

2011-10-18

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonate esters

C546S233000, C548S568000, C514S033000, C514S428000, C514S517000

Reexamination Certificate

active

08039656

ABSTRACT:
4-(trifluoromethanesulfonyloxyphenyl)propionic acid derivatives and pharmaceutical composition containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, these metabolites are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

REFERENCES:
patent: WO 00/24710 (2000-05-01), None
patent: WO 01/58852 (2001-08-01), None
patent: WO 02/068377 (2002-09-01), None
patent: WO 03/043625 (2003-05-01), None

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