2-(phenylamino) benzimidazole derivatives and their use as...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S388000

Reexamination Certificate

active

07960561

ABSTRACT:
This invention relates to novel 2-(phenylamino)benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels).In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

REFERENCES:
patent: 6518291 (2003-02-01), Saunders et al.
patent: 7228001 (2007-06-01), Kobayashi et al.
patent: 2002/0132842 (2002-09-01), Hofmeister et al.
patent: 2005/0054705 (2005-03-01), Heinelt et al.
patent: 2430412 (2002-06-01), None
patent: 1.358.741 (1964-04-01), None
patent: 1171904 (1969-11-01), None
patent: 2-306916 (1990-12-01), None
patent: WO-01/21160 (2001-03-01), None
patent: WO-02/46169 (2002-06-01), None
patent: WO-2004/069811 (2004-08-01), None
patent: WO-2004/098494 (2004-11-01), None
patent: WO-2005/044793 (2005-05-01), None
Sailer et al., “Comparative immunohistochemical distribution of three small-conductance Ca2±activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain,” Mol. Cell. Neurosci., 2004, vol. 26, pp. 458-469.
Liegeois et al., “Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry,” Current Medicinal Chemistry, 2003, vol. 10, pp. 625-647.
Zhu et al., “Studies on fluorine-containing aromatic heterocyclic compounds. 4. Reactions of 3-trifluoromethylphenyl and 2-chloro-5-trifluoromethylphenyl isocyanide dichlorides with bifunctional nucleophiles,” Journal of Fluorine Chemistry, 1989, vol. 43, No. 3, pp. 319-327.
Caplus Accession No. 2003:959005, Alagarsamy et al., “Antibacterial activity of some 2-(substituted amino) benzinidazoles,” Indian Pharmacist, 2003, vol. 2, No. 8, pp. 78-79.
Grimmett, “Product class 4: benzimidazoles,” Science of Synthesis, 2002, vol. 12, pp. 529-612.
Claramunt et al., “Aromatic systems with 10 .pi. electrons derived from 3a-azapentalene. XV. Heterocyclic derivatives from 3a-azapentalene by aryne synthesis,” Anales de Quimica, 1975, vol. 71, No. 2, pp. 206-207.
Murphy, “Carbonimidoyl dihalides as organic intermediates. I. The preparation of 2-aryl aminobenzimidazoles,” Journal of Organic Chemistry, 1964, vol. 29, No. 6, pp. 1613-1615.
Caplus Accession No. 1954:5037, Matsui et al., “Mothproofing agents for wool. XIII. Relation between teh chemical constitution of mothproofing agents and their effects on wool,” J. Soc. Org. Synthetic Chem., 1952, vol. 10, pp. 333-335.
Garin et al., “A facile synthesis of dimethyl N-aryldithiocarbonimidates and 2-arylaminobenzimidazoles,” Synthesis, 1983, pp. 375-376.
Tuncbilek et al., “Synthesis and antimicrobial activity of some new anilinobenzimidazoles,” Arch. Pharm. Pharm. Med. Chem., 1997, vol. 330, No. 12, pp. 372-376.
Caplus Accession No. 2001:732016, Krchnak et al., “Solid-phase traceless synthesis of selected nitrogen-containing heterocyclic compounds. The encore technique for directed sorting of modular solid support,” Vollection of Czechoslovak Chemical Communications, 2001, vol. 66, No. 7, pp. 1078-1106.
Omelka et al., “EPR study of nitroxyl radicals of substituted 5-anilinotriazoles, 5-anilinotetrazoles, and 2-anilinobenzimidazoles,” Collection of Czechoslovak Chemical Communications, 1992, vol. 57, No. 5, pp. 1065-1071.
Merchan et al., “Synthesis of 2-aryliminoimidazolidines and 2-arylaminobenzimidazoles from methyl n-arylditriocarbamates,” Synthesis, 1982, pp. 482-484.
Omar et al., “The cyclodesulfurization of thio compounds; XVI. Dicyclohexylbarbodiimide as an efficient cyclodesulfurizing agent in the synthesis of heterocyclic compounds from various thio compounds,” Synthesis, 1977, pp. 864-865.
Krchnak et al., “A solid phase traceless synthesis of 2-arylaminobenzimidazoles,” Tetrahedron Letters, 2001, vol. 42, pp. 1627-1630.
Jarrott et al., “Characterization of .alpha.-adrenoceptors in rat and guinea pig tissues using radiolabeled agonists and antagonists,” Circulation Research, 1980, vol. 46, No. 1, pp. 15-20.
Caplus Accession No. 1975:541756, Lebedeva et al., “Dependence of acute toxicity on structure in a series of 2-substituted benzimidzazoles,” Meditsinskaya Parazitologiya i Parazitarnye Bolezni, 1975, vol. 44, No. 3, pp. 316-322.
Jen et al., “Amidines and related compounds. 6. Studies on structure-activity relationships of antihypertensive and antisecretory agents related to clonidine,” Journal of Medicinal Chemistry, 1975, vol. 18, No. 1, pp. 90-99.
Caplus Accession No. 1990:178787, Kolesnikova et al., “Reaction of N-pentafluorophenylcarbonimidoyl dichloride with primary aminds,” Zhurnal Organischeskoi Khimii, 1989, vol. 25, No. 8, pp. 1689-1695.
Wang et al., “A practical synthesis of 2-(N-substituted)-amino-benzimidazoles utilizing CuCI-promoted intramolecular cyclization of N-(2-aminoaryl)thioureas,” Tetrahedron Letters, 2004, vol. 45, pp. 7167-7170.

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