Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-07-10
1987-05-26
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514212, 514234, 540600, 544119, 544287, A61K 31505, C07D23991, C07D40106
Patent
active
046686827
ABSTRACT:
Disclosed are a 2-phenylalkyl-3-aminoalkyl-4(3H)-quinazolinone compound of Formula (1): ##STR1## wherein, X represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a benzyloxy group, a halogen atom or a hydroxy group; Y represents an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a benzyloxy group, a halogen atom or a nitro group; R.sup.1 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; R.sup.2 represents an alkyl group having 1 to 5 carbon atoms or a group of Formula (2) ##STR2## [wherein, Z represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or a halogen atom; d is an integer of 1 to 3; and l is an integer of 1 to 5]; or R.sup.1 and R.sup.2 represent together with the nitrogen atom to which they are attached, a cyclic amino group of the formula: ##STR3## [wherein, A represents an alkylene group having 2 to 6 carbon atoms or a group of the formula --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --]; a and b are independently an integer of 1 to 3; and n and m are independently an integer of 1 to 5, or a pharmaceutically acceptable acid addition salt thereof, a process for preparing said compound, a composition comprising said compound as an active ingredient and a method of treatment by use of said compound.
The compounds of the present invention have calcium antagonistic, vasodilative, and antihypertensive activities.
REFERENCES:
patent: 3748327 (1973-07-01), Beyerle et al.
Boltze et al., "Chemical Abstracts", vol. 63, 1965, col. 4289d.
Dash et al., "Chemical Abstracts", vol. 94, 1981, col. 94:47259x.
Horii Daijiro
Ishibashi Akira
Sekiya Tetsuo
Tsutsui Mikio
Mitsubishi Chemical Industries Limited
Raymond Richard L.
Turnipseed James H.
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