2-phenyl- and 2-thienyl-(2)-piperidine derivatives having neurop

Details 2-phenyl- and 2-thienyl-(2)-piperidine derivatives having neurop 2-phenyl- and 2-thienyl-(2)-piperidine derivatives having neurop

1994-03-04

1998-02-03

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514326, 546192, 546213, 546232, 546240, A61K 31445, C07D21112, C07D21114, C07D40904

Patent

active

057145008

ABSTRACT:
Compounds of formula (I) ##STR1## in which R.sub.1 is hydrogen, R.sub.2 is hydrogen or C.sub.1-6 alkyl, R.sub.3 and R.sub.4 independently represent one or more radicals selected from hydrogen, NH.sub.2, NO.sub.2, halogen, hydroxy, C.sub.1-6 alkoxy or C.sub.1-6 alkyl, X represents S or --CH.dbd.CH-- group and pharmaceutically acceptable salts are NMDA receptor antagonists.

REFERENCES:
patent: 2524643 (1950-10-01), Walter
patent: 2636881 (1953-04-01), Schultz
patent: 5109017 (1992-04-01), Schmiesing
Zezza et al "Reaction of Organolithium Regeants" J. Org. Chem. 49 4397-99 (1984).
Leonard et al "Unsaturated Swines. X." J. Am. Chem. Soc. 79 5279-92 (1957).
Loew et al "Structure Activity Studies of Morphine Fragments" Eur. J. Med. Chem. 26 763-773 (1991).
Morrison & Boyd "Organic Chemistry" Allyn & Baem Co., p. 631, 746 (1973).

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