2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for

Details 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for

1997-07-16

1999-01-12

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 60, 502208, C07D21102, C07D21132

Patent

active

058592490

ABSTRACT:
Disclosed is a 2-phenyl-2-(2'-piperidinylidene)acetate derivative suitably used for a raw material of a 2-phenyl-2-(2'-piperidinyl)acetate derivative and a process for manufacturing the same. Also disclosed is a process for manufacturing an optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative which is a major intermediate for an antidepressant. The 2-phenyl-2-(2'-piperidinylidene)acetate derivative is manufactured by cyclizing a 7-(N-substituted amino)-3-oxo-2-heptanoate derivative. The optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative is manufactured by asymmetrically hydrogenating the 2-phenyl-2-(2'-piperidinylidene)acetate derivative in the presence of a complex of a Group VIII transition metal or an acid.

REFERENCES:
Gluchowski et al. "Preparation of dihydropyridine derivatives as drugs" CA 123:143638, 1994.

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