2-oxy-benzoxazinone derivatives for the treatment of obesity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S092000

Reexamination Certificate

active

07858617

ABSTRACT:
The use of a compound comprising formula (I):or a salt, ester, amide or prodrug thereof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them.In formula (I) A is a 6-membered aromatic or heteroaromatic ring; andR1is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups.

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Hays et al. “2-Amino-4H-3,1-benzoxazin-4-ones as Inhibitors of Clr Serine Protease”1 Med. Chem. 1998, 41, 1060-1067.
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Krantz et al. “Design of Alternate Substrate Inhibitors of Serine Proteases: Tactics for Obstructing Deacylation Pathways” Advances in Biosciences 1987, 65, 213-220.
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PCT/GB00/00032: International Search Report, mailed on Dec. 12, 2000.

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