2-Oxoazetidine derivatives and production thereof

Details 2-Oxoazetidine derivatives and production thereof 2-Oxoazetidine derivatives and production thereof

1981-11-13

1984-01-24

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602454, 2602452T, C07D20508, C07D40304, C07D48704

Patent

active

044275862

ABSTRACT:
2-Oxoazetidine derivatives represented by the formula; ##STR1## wherein R.sup.1 stands for phthalimido group, benzyloxycarbonylamino group, a halogen on an alkyl group which may have hydroxyl group, R.sup.2 stands for hydrogen, an alkyl group, an alkylthio group or an arylthio group, and R.sup.3 and R.sup.4 independently stand for an acyl group or cyano group, and a method of preparing them, which is shown by the following reaction scheme; ##STR2## wherein R.sup.5 stands for a carboxyl-protective group, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are of the same meanings as defined above.
This compound (I) can be utilized as intermediates for carba-2-penem compounds having excellent anti-bacterial activity and .beta.-lactamase inhibitory activity.

REFERENCES:
patent: 4262010 (1981-04-01), Christensen et al.
Shibuya et al., Heterocycles 12, 1315 (1979).
Oidu et al., Chem. Pharm. Bull. 28, 3494 (1980).

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