2-Oxo-benzimidazolyl substituted ethanolamine derivatives...

Details 2-Oxo-benzimidazolyl substituted ethanolamine derivatives... 2-Oxo-benzimidazolyl substituted ethanolamine derivatives...

2007-05-08

2007-05-08

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S306400

Reexamination Certificate

active

11228620

ABSTRACT:
The present invention relates to a β3adrenergic receptor agonist of formula (I), wherein R is C3–C8alkyl or (C3–C7cycloalkyl)C1–C5alk-di-yl: R1is H, CN, halo; C1–C6alkyl, C1–C4haloalkyl, CO2R6, CONR6R6, NR6COR7, NR6R6, OR6, SR6, SOR7, S02R7or SO2NR6R6; R1ais H, halo or C1–C6alkyl; R2is H or C1–C6alkyl; R3and R4are independently H or C1–C6alkyl R5is hydrogen, optionally substituted phenyl or optionally substituted heterocycle; X is absent or is OCH2or SCH2; X1is absent or C1–C5alk-di-yl; and X2is absent or is O, S, NH, NHSO2, SO2NH or CH2; or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity

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