2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines

Details 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines

1982-04-01

1986-05-06

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393R, 544333, 544334, 2602433, 544359, 544364, 2602444, 544366, 544369, 2602454, 544370, 544371, 2602455, 544372, 544367, 2602456, 544374, 544379, 2602457, 546187, 546193, 2603303, 546194, 546207, 2603304, 546209, 546210, 544182, 546211, 546212, 544215, 546213, 546256, 544279, 546275, 546276, 544295, 546278, 546279, 544296, 546280, 546281, 544300, 546283, 546284, 544301, 544310, 544311, 544312, 544316, 544317, 544319, 544320, 544321, 544322, 544323, 544324, 544325, 544326, 544327, 544331, 544332, C07D20

Patent

active

045870470

ABSTRACT:
Antibacterial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered heterocycle (R.sub.c), phenylalkyl, (substituted phenyl)alkyl, R.sub.c -alkyl or --NR.sub.a R.sub.b wherein R.sub.a and R.sub.b are the same or different and each is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl, or (substituted phenyl)alkyl or one of R.sub.a and R.sub.b is hydrogen, alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl and the other is amino, alkanoylamino, arylcarbonylamino, alkoxycarbonylamino, alkylsulfonylamino, alkylamino, dialkylamino, phenylamino, (substituted phenyl)amino, hydroxy, cyano, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, (substituted phenyl)alkoxy, R.sub.c, R.sub.c -alkyl, R.sub.c -alkoxy, alkylsulfonyl, alkylmethyleneamino, phenylmethyleneamino or (substituted phenyl)methyleneamino.

REFERENCES:
Aue et al., J. Org. Chem. 40, 2356 (1975).
Weyer et al., Chem. Abs. 95, 168964c (1981).

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